Changes in platelet-rich fibrin composition after trauma and surgical intervention

Changes in platelet-rich fibrin composition after trauma and surgical intervention

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Reconstruction surgery after trauma has always been a big challenge.The use of platelet-rich fibrin (PRF) as an autologous source could help accelerate the regeneration time of bone and soft tissues.PRF is a blood concentrate system obtained through a one-step centrifugation.The 3D matrix of the PRF clot serves as a reservoir of growth factors.In the present study, PRF from patients after trauma and after surgery was compared to healthy volunteers to evaluate the composition and potential of PRF as a possible autologous tool for growth factor delivering.

Two PRF Ceramic Ornament Gift Box species and blood from healthy volunteers and patients after trauma and after following surgical intervention were Shock Sensor compared (n = 10).FACS analysis, ELISA, and histological analysis were performed.The Pro-inflammatory potential after trauma and after the intervention is increased in PRF species whereas cellular and humoral factors with distinct regenerative potential remained on a level comparable to peripheral blood.It was demonstrated that cells in PRF express more pro-inflammatory species when obtained after the surgical intervention compared to PRF from healthy individuals.This pro-inflammatory potential should be considered, when combining PRF with bone substitute materials for reconstruction surgery prone to foreign body giant cell reaction.

Accordingly, solid or injectable PRF-based matrices should preferably be prepared prior to a surgical intervention.